- Acquires expertise in biology research spotlight on aging and age-onset neurodegeneration like Parkinson’s disease, and its connection with autophagy. I did B.Sc. and M.Sc. in Biochemistry from Rajshahi University, Bangladesh. During PhD in the Niigata University, Japan a quantitative method was established to assess autophagy more efficiently and quickly.
- In 2010, I joined at the University of Florida and a brief study was done on liver fibrosis and its response to autophagy and apoptosis. Extended to my research on neurodegeneration in 2011, I joined a group at the Institute for Translational Neuroscience, University of Minnesota to study molecular mechanism involving onset and progression of Parkinson’s disease (PD) using a well-established mouse models. This work consisted of multiple projects including basic mechanism of autophagy-lysosomal impairment, disease progression, cAbl-p53, mTOR signal mechanism, and small molecules and drugs targeting therapeutic intervention of PD.
- Meanwhile in 2016 I joined an NIH training grant “Functional Proteomics of Aging” in the Dept. of Visual Neuroscience, University of Minnesota and worked on autophagy and immunoproteasome. July 2018 I came back to the Lee lab and infused my time on Neurodegeneration focusing nilotinib, an FDA approved drug, that delay disease onset through alleviation of c-Abl/p53/mTOR signaling and autophagy activation. My long term research goal is making a significant impact on human lives through my findings.
• I have keen interest on (i) basic mechanism of autophagy, and (ii) signal transductionof autophagy, ER stress, mTOR pathway, cAbl-p53 pathway and tuning the signal cascade using small molecules and drugs for therapeutic intervention.
Razaul Karim, Ph.D.
Lab: Institute for Translational Neuroscience,
Department of Neuroscience,
University of Minnesota, Twin Cities Medical School
mailto:[email protected]
mailto:[email protected]
• I have keen interest on (i) basic mechanism of autophagy, and (ii) signal transductionof autophagy, ER stress, mTOR pathway, cAbl-p53 pathway and tuning the signal cascade using small molecules and drugs for therapeutic intervention.
Razaul Karim, Ph.D.
Lab: Institute for Translational Neuroscience,
Department of Neuroscience,
University of Minnesota, Twin Cities Medical School
mailto:[email protected]
mailto:[email protected]